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Biochemistry of pyrimidine nucleotide synthesis. Ribose base biosynthesis comes from the pentose phosphate pathway (PPP) in the cytosol. Mitochondrial TCA cycle metabolites oxaloacetate and aspartate (asp) supply three out of the four carbons in the diazine ring. •: Possible cytosolic-derived carbons, •: Possible mitochondrial-derived carbons. •: Nitrogen.
