Figure 3.

Case GM78. (A) The patient presented with a lymph node positive, grade 2 ILC at age 41; metastases to the left ovary, transverse colon, and omentum were diagnosed 8 years later. (B) Morphology and immunophenotype of tumours: the ovarian metastasis displayed two distinct morphological patterns; PR and GATA3 were lost during metastasis, while ER, AR, and FOXA1 remained positive. (C) Copy‐number profiling highlights the clonal nature of all tumours, together with evidence of intra‐tumour heterogeneity (e.g. 1p−, 1q−, and 20q+ in the metastases). (D) Targeted gene sequencing demonstrated shared mutations included CDH1 and AR (white boxes indicate that no mutation was detected). Of note, AR protein was still expressed at 3+ intensity in 100% of the tumour cells. The colon sample failed sequencing. BR, breast; Cxt, chemotherapy; LO, left ovary; OM, Omentum; XRT, radiation therapy.