Table 2.

Sanofi-Sponsored Studies with Administration of Medicines Involving Healthy Volunteers, Performed During the Years 2014, 2015, and 2016

Total Number of Studies Performed	Type and Number of Studies	Total Number of Healthy Volunteers Involved	Number of Studies Per Country
122	Pharmacokinetic studies (bioavailability, bioequivalence, drug-drug interaction): 113 “First-in-human” studies of new chemical entities (single or multiple ascending doses): 9	Approximately 4800*	Canada Brazil Romania Czech Republic Germany USA/Canada France India Malaysia USA China Indonesia Turkey Bulgaria Japan Rep. of Korea South Africa	40 19 15 8 7 6 5 4 4 4 3 2 2 1 1 1 1

^*Based on an average estimated number of 40 healthy volunteers per pharmacokinetic study.