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Effect of 4 weeks of weight loss interventions on body weight (a), serum oxidative stress biomarkers (b), and hepatic gene expression (c). Data are represented as mean and SEM, n = 6 − 10 animals/group. ∗ p < 0.05 vs. the Ad-L group, ∗∗ p < 0.01 vs. the Ad-L group, ∗∗∗ p < 0.001 vs. the Ad-L group, ∗∗∗∗ p < 0.0001 vs. the Ad-L group. Ad-L: ad libitum group; ER: energy-restriction group; EX: exercise group; EREX: energy restriction plus exercise group.
