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Liposomes are required for inhibition of aiPLA2 activity by PIP-2 in isolated mouse lungs.
| Conditions | aiPLA2 activity nmol/min/mg Prot. |
|---|---|
| No PIP | 8.72 ± 0.16 |
| PIP-2 in saline | 8.50 ± 0.26 |
| PIP-2 in liposomes | 1.55 ± 0.11 |
Lungs were perfused with PIP-2 added directly to the perfusate or encapsulated in liposomes prior to addition. After 15 min, lungs were cleared of perfusate, homogenized and aiPLA2 activity was measured. Results are mean ± range for n = 2.
