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. 2019 Jan 3;19:1. doi: 10.1186/s12883-018-1232-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Analysis of stiffness and heightened sensitivity indices for the 32 serially analyzed patients over a 2-year course. a: Mean number of stiff areas at 6 months intervals. There is a statistically significant increase (p < 0.0001, Friedman test – One way ANOVA) in the number of stiff areas (3.25 at 6 months rising to 4.15 at 24 months) during the observation period. b: Mean number of heightened sensitivity scores calculated at 6 months intervals. The observed increase (3.40 vs 3.65) is not statistically significant (p < 0.1195, Friedman test – One way ANOVA)