Table 2.

The strategies for avoiding transferred TCR mispairing with endogenous TCRs

Strategies	Research references
Editing TCRs
Generating dominant TCR constructs that can inhibited the endogenous TCRs	[15]
Promoting the disruption of the endogenous TCRs	[32]
Disrupting only the endogenous TCR α chain	[33]
Silenced endogenous TCR genes	[34]
Knockout endogenous TCRβ simultaneously transduction of transferred TCRs	[35]
Using different kinds of cells
γδT cells	[36]
CD4+ and CD8+ T cells without endogenous αβ TCRs	[35]
Hematopoietic stem cells	[37]
Reprogrammed T cells	[38]