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. 2019 Jan 3;20:1. doi: 10.1186/s12868-018-0483-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Diabetes-induced nociceptive behavior in the rat formalin test. a Temporal courses of the nociceptive behavior observed after injection of 0.5% formalin into the dorsal hind paw of normoglycemic and diabetic rats 21 days after streptozotocin injection. b, c Nociceptive behavior induced by 0.5% formalin during first and second phase in normoglycemic (NG) and diabetic rats 7, 14 and 21 days after streptozotocin injection. Data are expressed as mean ± SEM for 6 animals. *Significantly different with respect to the normoglycemic group (NG), determined by one-way ANOVA followed by the Dunnett’s test with a P < 0.05