Fig. 6.

PRAME plays a role in gene expression reprogramming during epithelial-to-mesenchymal transition. a PRAME overexpression results in upregulation of 11 and downregulation of 2 EMT-related genes as determined by the EMT RT2 Profiler qPCR assay. b Gene ontology analyses of PRAME-associated upregulated genes according to enrichment for biological processes and disease-inference. c TCGA and GTEx data analysis of PRAME mRNA expression in esophageal and ovarian cancer using the GEPIA web server. T, tumor (red); N, normal (gray). Boxplot represents median and IQR. *p < 0.05, One-way ANOVA with log₂FC cutoff ≥ 1.5 or ≤ − 1.5