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. 2019 Jan 3;7:1. doi: 10.1186/s40478-018-0656-4

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Biochemical studies. a RT-QuIC analysis: 15 μL of CSF collected from patients 1, 2 and 3 efficiently seeded the aggregation of recHaPrP (90–231) while CSF collected from patient with AD (referred to as control) did not. The mean ThT fluorescence values per sample were plotted against time. b Western blot analysis: frozen samples of frontal (GC) and cerebellar (CC) cortex from Case 1 showed the presence of type 1 PrP^Sc after digestion with PK (50 μg/mL). Frontal cortex of patients with type 1 and type 2 PrP^Sc were used as migration controls. Numbers on the right side of the WB indicate the molecular weight