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. 2019 Jan 3;16:1. doi: 10.1186/s12974-018-1391-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Repeated CXCL1 neutralizing antibody and NFκB inhibitor treatment attenuates mechanical allodynia caused by BCP. a BCP induced significant mechanical allodynia as shown by von-Frey tests. Injection of 8 μg/0.5ul and 4 μg/0.5ul CXCL1 neutralizing antibody showed an effective and reliable anti-allodynic effect in a dose-dependent manner on BCP. Drugs were given once a day from POD 6 to POD 9. n = 8, ***p < 0.001, **p < 0.01 compared with that of BCP + control serum group. ^###p < 0.001, ^##p < 0.01 compared with that of BCP + CXCL1 neutralizing antibody 4 μg group. There were eight rats in each group. b Repeated BAY11-7082 treatment at 1 μg showed no effect on mechanical allodynia, but 10 μg of this compound significantly attenuated mechanical allodynia (***p < 0.001, **p < 0.01 vs. BCP + PBS group; n = 8)