Table 1.

Frequency of histologic types of head and neck lymphoma including also epidemiology, symptomatology, disease manifestations, localization and laboratory findings

	Indolent lymphoma	Aggressive lymphoma	Highly aggressive lymphoma	Hodgkin lymphoma	p-value
n	77	110	6	28
Age					< 0.0001
Mean ± SD	72 ± 39	66 ± 16	41 ± 24	41 ± 21
Median	70	70	34	33
Gender, n [%]					0.11
Male	37 [48]	57 [52]	6 [100]	14 [50]
Female	40 [52]	53 [48]	0	14 [50]
First Diagnosis, n [%]	62 [81]	90 [82]	5 [83]	27 [96]	0.26
Time to diagnosis, [Months]					0.22
Mean ± SD	7.5 ± 11.5	3.7 ± 8.5	1.5 ± 0.7	3.4 ± 3.5
Median	3.0	2.0	1.5	1.5
Leading symptom					0.045
Cervical mass	62 [81]	76 [69]	3 [100]	27 [96]
Globus pharyngis	3 [4]	6 [5]	0	0
Odyno−/dysphagia	7 [9]	21 [19]	3 [100]	1 [4]
Dysphonia	0	1 [1]	0	0
Dyspnea	2 [3]	3 [3]	0	0
Incidentally	2 [3]	3 [3]	0	0
Localization, n [%]					< 0.0001
Major salivary gland	21 [27]	12 [11]	0	0
Sinonasal system	2 [3]	4 [4]	0	0
Tonsils	15 [20]	41 [37]	3 [50]	1 [4]
Hypopharynx/Larynx	1 [1]	6 [6]	0	0
Lymph node	37 [48]	43 [39]	3 [50]	27 [96]
Other	1 [1]	4 [4]	0	0
Laterality, n [%]					0.62
Unilateral	65 [85]	90 [82]	6 [100]	22 [79]
Bilateral	12 [15]	20 [18]	0	6 [21]
Systemic disease, n [%]	43 [56]	75 [68]	6 [100]	22 [79]	0.90
B-symptoms, n [%]	5 [7]	20 [18]	0	3 [11]	0.30
Laboratory parameter, Mean ± SD
Leucocytes	11.8 ± 12.0	7.7 ± 3.6	4.5 ± 3.2	8.0 ± 3.0	0.043
Hemoglobin	13.6 ± 1.9	13.4 ± 2.3	10.4 ± 6.1	13.0 ± 2.9	0.24
CRP	1.53 ± 2.88	1.80 ± 3.00	1.20 ± 2.00	3.30 ± 4.30	0.15
LDH	263 ± 285	278 ± 291	232 ± 229	271 ± 121	0.97

aNHL Aggressive non-Hodgkin lymphoma, haNHL Highly aggressive non-Hodgkin lymphoma, HL Hodgkin lymphoma, iNHL Indolent non-Hodgkin lymphoma