Table 2.
This table summarize all adult cases of neuroborreliosis related transverse myelitis reported in English literature. It includes patients’ demographics, country of origin, most common symptoms and signs as well as treatment and outcome of the diseases.
| Case (Ref) |
Year | Age (y/o) |
Sex | Country | Systemic illnesses |
Time between symptom onset and diagnosis | Diagnostics | Oligoclonal bands | Erythema migrans | Autonomic dysfunction | Sensory level | Images | Therapy | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 ([8]) |
1986 | 19 | F | Belgium | none | 2 weeks | CSF WBC-10, 90% lymphocytes; + Serum antibodies (IgG) |
Positive | Yes | None | T4 | No | Penicillin G for 2 weeks | Improved |
| 2 ([9]) |
1995 | 42 | M | UK | none | 5 days | LP not done (patient declined) Serum antibodies positive (not specified IgM or IgG) |
N/A | Yes | None | C5-6 | MRI | Cefotaxime 6 g/day for 1 week then 8 weeks of doxycycline | Improved |
| 3 ([10]) |
2002 | 40 | M | France | none | 1 week | CSF WBC-205, 90% lymphocytes. CSF antibodies IgM and IgG positive |
Yes | Yes | Urinary and bowel incontinence | C2 | MRI | Ceftriaxone 2 g/day for 3 weeks. | Improved |
| 4 ([11]) |
2005 | 50 | M | France | none | 4 weeks | CSF WBC-16, 100% lymphocytes; Intrathecal B.burgdorferi Ab production + Serum and CSF PCR+ |
Yes | No | None | Not reported | MRI | Ceftriaxone 4 weeks, doxycycline 4 weeks and IV steroids | Improved |
| 5 ([12]) |
2008 | 46 | F | Georgia, USA | none | 3 weeks | Positive antibodies in blood (IgM and IgG) | Negative | No | Urinary retention, constipation | T6 | MRI | Ceftriaxone for 1 week plus doxycycline for 3 weeks plus IV Methylprednisolone |
Improved |
| 6 ([13]) |
2009 | 21 | F | Turkey | none | 3 months | CSF WBC-20, 86% lymphocytes. CSF and serum antibodies + (IgM and IgG) |
Negative | No | None | T11 | MRI | Ceftriaxone 4 g/day for 28 days plus (200 mg/day of doxycycline | Improved |
| 7 Our case |
2018 | 25 | M | Wisconsin, USA | none | 2 weeks | CSF WBC 316, 76% lymphocytes, + CSF B.burgdorferi PCR |
Negative | Yes | Urinary retention, constipation |
T5 | MRI | IV ceftriaxone (28 days) and IV Methylprednisolone (3 days) | Improved |