Table 6.
Hormonal levels according to neuroradiology and gender.*
| Males |
Females |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| no. | yrs | ES | Cortis (µg/dl) |
TSH (mU/L) |
IGF-1 (ng/ml) |
no. | yrs | ES | Cortis (µg/dl) |
TSH (mU/L) |
IGF-1 (ng/ml) |
|
| 1 | 9 | 33 | PES | 12.9 | 1.64 | 84 | 101 | 50 | PES | 27.2 | 11.6 | 81 |
| 2 | 78 | 34 | PES | 18.8 | 1.38 | 205 | 43 | 56 | PES | 21.1 | 1.04 | 128 |
| 3 | 42 | 35 | PES | 8.2 | 1.62 | 75 | 72 | 56 | PES | 9.6 | 2.71 | 99 |
| 4 | 82 | 40 | PES | 18.1 | 0.47 | 90 | 79 | 41 | TES | 25.7 | 0.02 | 72 |
| 5 | 75 | 42 | PES | 5.8 | 1.64 | 130 | 99 | 58 | TES | 5.9 | 1.13 | 89 |
| 6 | 31 | 45 | PES | 20.8 | 1.0 | 71.3 | 58 | 62 | TES | 25.5 | 0.71 | 154 |
| 7 | 104 | 60 | PES | 6.4 | 1.39 | 125 | 29 | 65 | TES | 22.3 | 0.06 | 29 |
| 8 | 74 | 71 | PES | 15.3 | 0.41 | 52 | 12 | 68 | TES | 15.2 | 0.64 | 93 |
| 9 | 95 | 71 | PES | 13.4 | 1.62 | 138 | 80 | 71 | TES | 12.7 | 1.37 | 110 |
| 10 | 97 | 79 | PES | 1.9 | 0.48 | 150 | 93 | 72 | TES | 4.8 | 0.02 | 87 |
| 11 | 81 | 81 | PES | 21.9 | 1.0 | 103 | 62 | 73 | TES | 17.3 | 0.54 | 206 |
| 12 | 34 | 84 | PES | 5.3 | 0.62 | 78 | 89 | 73 | TES | 9.2 | 0.73 | 122 |
| 13 | 28 | 67 | TES | 6.3 | 0.29 | 55 | 38 | 75 | TES | 21.3 | 1.37 | 61 |
| 14 | 36 | 71 | TES | 21.5 | 1.52 | 91 | 55 | 79 | TES | 22.6 | 1.0 | 24 |
| 15 | 13 | 73 | TES | 13.9 | 0.8 | 158 | 98 | 81 | TES | 24.5 | 0.64 | 114 |
| 16 | 5 | 86 | TES | 13.5 | 0.41 | 60 | 10 | 85 | TES | 47.0 | 1.13 | 67 |
| 17 | 91 | 86 | TES | 28.9 | 1.52 | 99 | 54 | 88 | TES | 31.9 | 2.25 | 105 |
| 18 | 23 | 88 | TES | 13.6 | 0.47 | 76 | 41 | 89 | TES | 23.3 | 0.66 | 50 |
| 19 | 103 | 91 | TES | 18.0 | 2.72 | 73 | 69 | 90 | TES | 20.1 | 0.73 | 72 |
| PES + TES (n = 19) |
13.9 ± 7.0 [13.6] 1.9–28.9 |
1.05 ± 0.53 [1.0] 0.29–2.72 |
100.7 ± 40.4 [90] 52–205 |
PES + TES (n = 19) |
20.4 ± 9.9 [21.8] 4.8–47.0 | 0.93 ± 0.70 [0.73] 0.02–2.71 |
92.8 ± 42.8 [89] 24–206 |
|||||
| PES (n = 7) |
12.4 ± 6.8 [13.1] 1.9–21.9 | 1.02 ± 0.53 [1.0] 0.41–1.64 |
108.4 ± 42.9 [96.5] 52–205 |
PES (n = 3) |
19.3 ± 8.9 [21.1] 9.6–27.2 |
1.04, 2.71 | 102.7 ± 23.7 [99] 81–128 |
|||||
| TES (n = 12) |
16.5 ± 7.2 [13.9] 6.3–28.9 |
0.96 ± 0.61 [0.80] 0.29–2.72 |
87.4 ± 34.8 [76] 55–158 |
TES (n = 16) |
20.6 ± 10.3 [21.8] 4.8–47 |
0.81 ± 0.57 [0.72] 0.02–2.25 |
90.9 ± 45.8 [88] 24–206 |
|||||
| Normal (n = 42) |
14.5 ± 5.5 [13.9] 3.1–27.3** |
1.63 ± 0.96 [1.39] 0.48–5.06 |
134.5 ± 85.2 [104] 41–354 |
Normal (n = 23) |
18.8 ± 8.6 [19.6] 5.8–34.6** |
1.39 ± 1.02 [0.96] 0.005–3.45 |
101.0 ± 50.7 [88] 27–233 |
|||||
| Normal vs PES + TES | P = 0.86 | P = 0.019 | P = 0.27 | Normal vs PES + TES | P = 0.64 | P = 0.20 | P = 0.79 | |||||
For females, means ± SD, median and ranges were calculated by omitting case no. 1, who is suspicious for subclinical primary hypothyroidism.
*
Abbreviations: ES = empty sella; PES = partial empty sella; TES = total empty sella; Cortis = cortisol. There was neither borderline nor statistical significant difference when comparing cortisol, TSH or IGF-1 in the PES group with the corresponding analyte in the TES group. Cortisol, TSH or IGF-1 are typed bold face when subnormal.
**
In the intergender comparison, significant was only one difference in the normal group and regarded cortisol (14.5 ± 5.5 vs 18.8 ± 8.6 µg/dl, P = 0.017 by ANOVA).