Table 1.
Membrane potential changes of Layer 2/3 pyramidal neurons during cortical spreading depression in vivo and in vitro
| Parameters | Median | Range | 25th–75th percentile |
|---|---|---|---|
| In vivo | |||
| Maximum depolarization amplitude (mV) | +10 | −7 to 25 | 4 to 16 |
| Depolarization duration (s) | 237.5 | 137.6 to 345.6 | 203.4 to 301.3 |
| Total amplitude (mV) | 59.11 | 33.29 to 71.17 | 52.67 to 66.68 |
| Depolarization ramp | |||
| Amplitude (mV) | 9.75 | 2.26 to 16.08 | 8.10 to 10.50 |
| Duration (s) | 28.13 | 13.94 to 50.98 | 21.09 to 30.58 |
| Change in Vm after recovery (mV) | 0.5 | −6.7 to + 7.4 | −4.9 to 3.6 |
| In vitro | |||
| Maximum depolarization amplitude (mV) | −10.85 | −54.6 to +1.8 | −33.25 to −16 |
| Depolarization duration (s) | 337.3 | 181.7 to 430 | 201.4 to 371.1 |
| Total amplitude (mV) | 54.15 | 29.30 to 74.50 | 30.60 to 66.35 |
| Change in Vm after recovery (mV) | −0.9 | −8.5 to + 7.3 | −2.78 to 3.68 |