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. 2019 Jan 3;7(1):e13961. doi: 10.14814/phy2.13961

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© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Delayed latency to seizure in response to ketone supplementation in Sprague‐Dawley rats. (A) A scatter plot (including outliers) demonstrating the latency to seizure (LS) for all specimens in the different treatment groups. KE + MCT group had significantly increased LS compared to control (P = 0.049). (B) The latency to seizure (LS) is presented after the exclusion of the outliers (2SD) from each treatment group. The LS was significantly delayed in the KE (P = 0.0003), KE+ MCT (P = 0.028) and KE/2 (P = 0.023) treatment groups when compared to control. LS in KE group was significantly higher than in KE/2 group (P = 0.011). (C) The percent change in latency to seizure (LS) when compared to control. (D) The blinded experimenter opening the hyperbaric chamber after determining seizure severity and performing gradual decompression.