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. 2019 Jan 3;7(1):e13961. doi: 10.14814/phy2.13961

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© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Changes in blood ketone levels in response to ketone supplementation. (A) All treatment groups showed a significant increase in blood D‐β HB concentrations. Compared to the control, the KE (P < 0.0001) and KE+MCT (P = 0.0002) groups had a higher level of D‐β HB by a factor of five, KE/2 group (P = 0.0012) by a factor of three, and the KS+MCT group (P = 0.0006) by a factor of approximately two. (B) There was a positive correlation between latency to seizure (LS) and blood D‐β HB concentration (R ²=0.5889). (C) The AcAc levels measured 60 min after treatment for the different treatment groups. The KE (P < 0.0001), KE+MCT (P < 0.0001) and KE/2 (P < 0.0001) groups had significantly elevated AcAc levels, compared to control.