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. 2019 Jan 1;33(1-2):55–60. doi: 10.1101/gad.319939.118

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© 2019 Cohen et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Perturbed cell adhesion in Ring1a/b double-knockout skin epidermis. (A) Toluidine blue staining of semithin skin sections. Bar, 25 µm. (B–D) TEM ultrastructural analyses of control and Ring1a/b double-knockout skins. (B) Representative region of skin epidermis. Bar, 10 µm. (C) High magnification of epidermal basement membrane region. Bar, 0.5 µm. (D) High magnification of cell–cell adhesion region between basal and spinous layers of skin epidermis. Bar, 0.5 µm. (E) IF staining for KRT6 (green). The basement membrane is labeled by ITGα6 (red). Bar, 25 µm. (Der) Dermis; (BL) basal layer; (Sp) spinous layer; (Gr) granular layer; (SC) stratum corneum; (HD) hemidesmosome; (D) desmosome; (Kf) keratin intermediate filaments.