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. Author manuscript; available in PMC: 2019 Jan 3.
Published in final edited form as: Neurobiol Aging. 2015 Dec 31;39:195–201. doi: 10.1016/j.neurobiolaging.2015.12.017

Figure 2.

Figure 2.

A. Photomicrograph showing blood vessels stained with the pan-Aβ antibody MOAB-2 in the frontal cortex of a 38 year-old female gorilla. B and C. Aβ42 and Aβ40 plaques in the cingulate cortex (area 24) in a 42 year-old female gorilla, respectively. D. Thioflavine S (Thio) positive blood vessel in the area 24 of a 42 year-old female gorilla. Note the stronger thioflavine S fluorescence in the blood vessel (yellow arrow) compared to the plaques (white arrows). E. Dual immunolabeling showing APP/Aβ-positive accumulations (brown) in close apposition to the CD31-ir blood vessels (dark blue) in the frontal cortex of a 42 year-old female gorilla. F and G. Dual immunolabeling showing the absence of dystrophic SMI-34-ir neurites (brown) within the surrounding of a Aβ−42 positive plaque (dark blue) in the frontal cortex of a 42 year-old female gorilla (F), while numerous swollen and dystrophic SMI-34-ir neurites (brown) are seen within the Aβ42 positive plaque in the cortex of an AD case (G). Scale bars = 100 μm in A; 50 μm in B and C; 25 μm in D, E, F, G.