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. 2018 Jul 19;78(1):100–110. doi: 10.1136/annrheumdis-2017-212863

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Characterisation of ProCs, preHTCs and HTCs, and the definition of HTC subsets. (A) Heatmap showing the scaled expression of the top 20 differentially expressed genes defining the ProC, preHTC and HTC populations. (B) Boxplots showing the expression levels of transcription factors specifically expressed in different cell types. (C) Monocle pseudotime trajectory revealing the progression of ProCs, preHTCs and HTCs. (D) Pseudotemporal expression dynamics of specific representative genes (corresponding to (A)) marking ProCs, preHTCs and HTCs. All single cells in the ProC, preHTC and HTC cell lineage are ordered based on pseudotime. (E) t-SNE visualisation of the HTC-A and HTC-B subpopulations. (F) Heatmap showing the scaled expression of the top 10 differentially expressed genes defining the HTC-A and HTC-B subsets. HTCs, hypertrophic chondrocytes; preHTCs, prehypertrophic chondrocytes; ProCs, proliferative chondrocytes; t-SNE, t- distributed stochastic neighbour embedding.