Fig. 3.

Comparability of HILIC-UHPLC-FLD (participant 2) (left), xCGE-LIF (middle), and MALDI-TOF-MS (right) for the detection of clinical characteristics of pregnancy, RA and RA disease activity. (A) Comparability of single glycan signals (% area) with pregnancy (preconception = pc, third trimester of pregnancy = tm3, 26+ weeks postpartum = pp3), and RA (healthy = white, RA = gray). (B) Comparability of derived glycosylation traits with pregnancy and RA. (C) Derived trait differences detected uniquely by a single method with pregnancy and RA. (D) Association of derived glycosylation traits with RA disease activity (DAS28(3)-CRP). For a legend of the derived traits see supplemental Table S6.