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. Author manuscript; available in PMC: 2019 Jan 3.
Published in final edited form as: J Am Chem Soc. 2017 May 2;139(18):6363–6368. doi: 10.1021/jacs.7b00530

Figure 4.

Figure 4.

Autocatalytic system with four-arm junction substrates. (A) A simplified schematic of the autocatalytic system (see Figure S19 for details). P8au has catalytic domains to perform exponential amplification. Two nt were added at the 5′ end of domain 1 and the 3′ end of domain 2 to generate domains 1x and 2y, respectively. (B) Kinetic traces with different concentrations of the catalyst C1x. [S5au] = [S6au] = 10 nM, [R] = 20 nM.