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. 2018 Nov 26;140(50):17580–17590. doi: 10.1021/jacs.8b09609

Figure 4.

Figure 4

Mutant cycles that show the effect of S154A mutations on: (A) stabilization of the transition state for wild-type ScOMPDC-catalyzed decarboxylation of OMP by interactions with Q215; (B) stabilization of the transition state for wild-type ScOMPDC-catalyzed decarboxylation of OMP by interactions with Y217F; (C) stabilization of the transition state for Y217F ScOMPDC-catalyzed decarboxylation of OMP by interactions with R235; (D) stabilization of the transition state for wild-type ScOMPDC-catalyzed decarboxylation of OMP by interactions with R235A; (E) stabilization of the transition state for R235A ScOMPDC-catalyzed decarboxylation of OMP by interactions with Y217F.