Postmenopausal women with acute climacteric syndrome

Lower sexual appetite or sexual dysfunction Mood swings Accelerated bone loss (osteoporosis prevention during the early postmenopausal period Anamnesis of premenopausal mastalgia and breast tension High breast density Myomas Urogenital problems

Transfer from MHT to tibolone

Mastalgia or breast tension Increased breast density with need to repeat mammography or when the mammogram is unreadable Mood swings Sexual appetence disorders Irregular bleeding without a histopathological finding

Women without acute climacteric syndrome

Lowered sexual appetence Mood swings Osteopenia

Younger women – possible use

Premature ovarian failure – with sexual dysfunction and mood swings Long-term add-back therapy of agonists GnRH

GnRH, gonadotropin-releasing hormone; MHT, menopause hormone therapy.