Table 1. X-ray diffraction data for lipid-raft mixtures in the presence of halogenated anesthetics.
%Δ1H indicates the percentage change in the ratio of first-order diffraction peaks Lo/Ld upon adding anesthetic. %MAC indicates the concentration used as a percentage of the minimum alveolar concentration necessary for humans. At least two experiments on separate samples were performed for each anesthetic. Mean values are tabulated with standard errors. Reprinted with permission from Weinrich & Worcester (2013 ▸). Copyright 2013 American Chemical Society.
Mixture | Anesthetic | %Δ1H | %MAC |
---|---|---|---|
DOPC:DPPC/cholesterol 1:1/0.2 | |||
Halothane | 31 ± 3 | 270 ± 60 | |
Isoflurane | 17 ± 2 | 121 ± 22 | |
Chloroform | 22 ± 2 | 167 ± 17 | |
DOPC:SPM/cholesterol 1:1/0.2 | |||
Halothane | 21 ± 5 | 540 ± 20 | |
Isoflurane | 20 ± 3 | 300 ± 60 | |
Chloroform | 25 ± 8 | 262 ± 26 |