Figure 5.
Expression profiles of selected genes and pathways exhibit dynamic changes. Normalized RNA expression levels from PDGFrα-selected fibroblasts isolated from uninjured (UN) kidneys; or AKI kidneys at 3, 7, or 14 days post-FA; or kidneys 4 days post-UUO. RNAs were assayed with Affymetrix microarrays in triplicate from three independent sorted samples, with data points representing the mean. Expression levels are relative to UN and graphed on a log2 scale. Signaling pathways include TGF-β–related, WNT-related, and other ligands or receptors. ECM genes include the collagen family, the matrix metalloproteinase (MMPs), and the tissue inhibitors of MMPs (TIMPs).