Table 2.

Pathway analyses of gene expression in response to TGFβ or PGE2

Gene Cluster	Pathways	P Value	# Genes	Sourcea
TGF-β: Genes upregulated
	Genes upregulated in MEFs by TGFβ	3.8E−43	71 of 199	T
	Hif1α transcription	2.1E−14	25 of 65	T
	Glucose metabolism	2.9E−10	23 of 81	T
	Hif1α	1.6E−11	21 of 67	G
	Carbohydrate metabolism	1.9E−8	39 of 276	G
TGF-β: Genes downregulated
	Genes downregulated in MEFs by TGFβ	1.4E−43	77 of 244	T
	Cell adhesion	2.1E−21	176 of 1530	T
	Cell migration	2,6E−20	155 of 1300	T
	ECM and associated proteins	7.2E−14	119 of 1028	T
	ECM organization	5.7E−7	37 of 298	G
	Cell invasion	6.0E−9	76 of 845	G
PGE2: Genes upregulated
	Genes downregulated in MEFs by TGFβ	4.3E−37	51 of 244	T
	Proteinaceous ECM	1.2E−7	28 of 379	T
	Smad-related signaling	2.1E−4	25 of 491	G
	ECM components	3.4E−6	12 of 120	G
PGE2: Genes downregulated
	Genes upregulated in MEFs by TGFβ	1.8E−69	71 of 199	T
	Regulation of cell death	4.6E−18	100 of 1650	T
	Smad signaling	2.9E−6	31 of 491	G
	Matrix metalloproteases	1.3E−5	23 of 331	G
	Fibrosis	6.4E−11	25 of 268	G

^aT, ToppGene; G, Genomatix.