Figure 7.

Therapeutic peptides improve renal cell survival after ischemic stress. Peptides designed to reduce nucleophosmin (NPM)-Bax complex formation (Bax peptide) or interfere with phosphorylation changes that regulate NPM toxicity (peptides 2 and 3) significantly improve cell survival after ischemic stress (n=4; upper panel). Peptide 2 replicates regulatory phosphorylation sites located at the amino terminus (T⁸⁶, S⁸⁸, and T⁹⁵). Peptide 3 replicates regulatory phosphorylation sites located at the carboxy terminus (T²³⁴ and S²⁴²). The amino acid sequences of each of the three peptides designed to interfere with NPM function are shown (lower panel). *P<0.05 versus control peptide (CTL).