Table 1.
Renoprotective effect of peptide therapy for AKI
| Days (Post-AKI) | Peptide Treated, n=8 Animals at Each Time Point (Dose Post-AKI, h) | Control, n=6 Animals at Each Time Point (Dose Post-AKI, h) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0° | 1° | 2° | 3° | 4° | 5° | 6° | 0° | 1° | 2° | 3° | 4° | 5° | 6° | |
| 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | |||
| 2 | 1 | 1 | 1 | 4 | 6 | 4 | 4 | 3 | 4 | 2 | 3 | 4 | 4 | |
| 3 | 3 | 2 | 3 | 3 | 2 | |||||||||
| Total deaths | 1 | 2 | 1 | 1 | 8 | 7 | 7 | 6 | 6 | 5 | 6 | 6 | 6 | 5 |
| Survival, % | 88 | 75 | 88 | 88 | 0 | 13 | 13 | 0 | 0 | 17 | 0 | 0 | 0 | 17 |
Summary of animal survival data after transient renal ischemia; experimental conditions were identical to those described in Figure 8. A single dose of blocking peptide or a control peptide was administered at 0, 1, 2, 3, 4, 5, and 6 h after AKI induction. Animal deaths were presumed due to AKI, and they were recorded for 7-d postpedicle clamp release; no deaths were observed after 3 d. Significant protection by the blocking peptide on animal survival was observed for doses administered at 0, 1, 2, or 3 h post-AKI (P<0.05); the blocking peptide was not protective if administered at 4, 5, or 6 h post-AKI (P>0.05).