Table 2.
Adjusted differences in blood pressure and echocardiographic parameters between diuretics (chlorthalidone/amiloride) and losartan treatment groups*
| Variable | Drug | Baseline | 18-Month Follow-Up | Change from baseline | p | Between group change | p | Adjusted between group change** | p |
|---|---|---|---|---|---|---|---|---|---|
| SBP (mmHg) | Diuretics | 142.2 ± 8.2 | 129.8 ± 10.0 | -12.4 ± 11.1 | < 0.001 | 2.7 | 0.18 | 1.18 | 0.51 |
| Losartan | 139.4 ± 6.0 | 129.7 ± 8.7 | -9.7 ± 9.4 | < 0.001 | |||||
| DPB (mmHg) | Diuretics | 90.6 ± 5.9 | 83.7 ± 7.0 | -6.8 ± 5.9 | < 0.001 | 1.2 | 0.33 | 0.77 | 0.49 |
| Losartan | 90.2 ± 5.6 | 82.1 ± 6.8 | -8.0 ± 6.6 | < 0.001 | |||||
| LVMI (g/m2) | Diuretics | 84 ± 17 | 81 ± 19 | -3 ± 16 | 0.11 | 1.78 | 0.48 | 3.84 | 0.14 |
| Losartan | 82 ± 17 | 77 ± 16 | -4 ± 14 | 0.02 | |||||
| IVST (mm) | Diuretics | 10.0 ± 1.2 | 9.7 ± 1.3 | -0.3 ± 1.2 | 0.03 | 0.34 | 0.13 | 0.60 | 0.009 |
| Losartan | 10.0 ± 1.1 | 9.4 ± 1.2 | -0.7 ± 1.1 | < 0.001 | |||||
| PWT (mm) | Diuretics | 10.1 ± 1.1 | 9.5 ± 1.1 | -0.6 ± 3.3 | < 0.001 | -0.13 | 0.47 | 0.16 | 0.38 |
| Losartan | 9.8 ± 1.1 | 9.4 ± 1.0 | -0.46 ± 1.1 | 0.002 | |||||
| RWT | Diuretics | 0.45 ± 0.06 | 0.42 ± 0.05 | -0.04 ± 0.06 | < 0.001 | -0.009 | 0.47 | 0.007 | 0.53 |
| Losartan | 0.44 ± 0.06 | 0.41 ± 0.05 | -0.03 ± 0.07 | 0.006 | |||||
| LAVI (ml/m2) | Diuretics | 25.4 ± 6.5 | 24.1 ± 6.9 | -1.4 ± 6.2 | 0.12 | 1.24 | 0.28 | 0.26 | 0.83 |
| Losartan | 28.2 ± 7.8 | 25.7 ± 5.9 | -2.6 ± 5.2 | 0.001 | |||||
| Medial E/e’ ratio | Diuretics | 8.1 ± 2.1 | 8.5 ± 2.6 | 0.42 ± 2.52 | 0.23 | 0.61 | 0.21 | 0.22 | 0.65 |
| Losartan | 8.8 ± 2.3 | 8.6 ± 2.3 | -0.19 ± 2.39 | 0.57 | |||||
| EDT (ms) | Diuretics | 229.2 ± 47.4 | 252.2 ± 67.2 | 23.0 ± 63.0 | 0.01 | 11.0 | 0.37 | 13.33 | 0.34 |
| Losartan | 230.0 ± 45.4 | 243.8 ± 66.9 | 12.0 ± 64.2 | 0.19 |
*
Diuretics: n = 56; Losartan: n = 54.
**
Analysis of covariance adjusted for mean blood pressure variation, corresponding baseline echocardiographic parameter and time between randomization and echocardiographic exam. Diuretics: chlorthalidone/amiloride; SBP: systolic blood pressure; DBP: diastolic blood pressure; LVMI: left ventricular mass index; IVST: interventricular septum thickness; PWT: posterior wall thickness; RWT: relative wall thickness; LAVI: left atrial volume index; EDT: E-wave deceleration time. Data are expressed as mean ± SD.