TABLE 4.
Characteristic | Epoch 1, N = 838 | Epoch 2, N = 838 | Epoch 3, N = 833 | Epoch 4, N = 743 |
---|---|---|---|---|
Marital status: Single | 1.6 (1.0–2.5)a | 1.6 (1.0–2.6)a | 1.7 (1.1–2.8)a | 1.8 (1.1–3.1)a |
Prepregnancy BMI ≥25: Yes | 1.6 (1.1–2.5)a | 1.7 (1.1–2.6)a | 1.8 (1.1–2.7)a | 1.8 (1.1–2.9)a |
Passive smoking: Yes | 0.8 (0.5–1.4) | 0.8 (0.4–1.4) | 0.8 (0.4–1.4) | 1.0 (0.5–1.8) |
Chorionic plate inflammation: Yes | 0.6 (0.3–1.1) | 0.5 (0.3–1.0) | 0.5 (0.3–1.0) | 0.6 (0.3–1.3) |
Multiple-fetal gestation: Yes | — | 1.0 (0.6–1.6) | 0.9 (0.6–1.5) | 1.1 (0.6–1.9) |
Birth wt z score: <−1 | — | 0.6 (0.3–1.1) | 0.6 (0.3–1.1) | 0.6 (0.3–1.3) |
Definite tracheal infection | — | — | 1.0 (0.6–1.7) | 1.1 (0.6–1.9) |
Sedation, d 1–28 | — | — | 0.6 (0.3–1.0) | 0.5 (0.3–0.9)b |
Top quartile wt gain: Y 1 | — | — | — | 2.4 (1.5–3.9)a |
Top quartile wt gain: Y 2 | — | — | — | 1.5 (0.9–2.5) |
Children in each percentile category are compared with the same referent group of children with a BMI <85. All models account for the correlations between children from the same pregnancy. Epoch 1 candidates include the following characteristics: race, single marital status, prepregnancy BMI ≥25, passive smoke exposure, got pregnant while using birth control, aerobic bacteria isolated from the placenta, inflammation of the chorionic plate, Cesarean delivery, and/or membranes ruptured >24 h. Epoch 2 candidates include the following characteristics: child’s sex, birth wt z score <−1, multiple-fetal gestation. Epoch 3 candidates include the following characteristics: lowest quartile for GA of lowest MAP in first 24 h, lowest quartile for GA on 2 of the first 3 postnatal days for Pao2, definite tracheal infection, conventional mechanical ventilation or high-frequency ventilation on d 7, and/or sedation in the first 28 d. Epoch 4 candidates include the following characteristics: top quartile wt gain from birth to 1 y, top quartile wt gain from 1 to 2 y, and/or 1 or both parents unemployed. GA, gestational age; MAP, mean arterial pressure; —, not applicable.
Denotes OR that is statistically significantly increased.
Denotes OR that is statistically significantly reduced.