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. 2018 Nov 26;43(2):709–716. doi: 10.3892/ijmm.2018.3999

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of AST on mTORC1/p70S6K signaling in HK-2 cells. (A) Western blot analysis of p-mTOR. (B) Densitometry analysis of p-mTOR. (C) Western blot analysis of p-p70S6K. (D) Densitometry analysis of p-p70S6K. Data are expressed as mean ± standard error. n=3. ^**P<0.01 vs. NG group; ^#P<0.05 vs. HG group; ^##P<0.01 vs. HG group. AST, astragaloside IV; NG, normal glucose 5.56 mmol/l; MA, normal glucose 5.56 mmol/l + mannitol 54.44 mmol/l; HG, high glucose 60 mmol/l; Rap, high glucose + 20 nmol/l rapamycin; ASTL, high glucose + 50 µg/ml AST; ASTM, high glucose + 100 µg/ml AST; ASTH, high glucose + 200 µg/ml AST; p- phospho-; mTOR, mammalian target of rapamycin; p70S6K, ribosomal protein S6 kinase β-1.