Table II.
Crocin regulated the levels of ROS, SOD and GSH-Px in the serum, cerebral cortex and hypothalamus.
| Control | Crocin (20 mg/kg) | AlCl3 + d-gal | Crocin (mg/kg)
|
||
|---|---|---|---|---|---|
| 5 | 20 | ||||
| Serum | |||||
| ROS (U/ml) | 450.8±4.5 | 475.5±6.3 | 540.6±5.9b | 532.5±6.5 | 491.3±18.0d |
| SOD (U/ml) | 331.4±7.5 | 317.5±13.4 | 277.5±5.0b | 309.2±7.7d | 336.3±13.7e |
| GSH-Px (U/ml) | 780.0±21.4 | 756.3±17.7 | 632.8±20.8b | 685±14.9 | 775±24.4e |
| Cerebral cortex | |||||
| ROS (U/mgprot) | 286.3±24.8 | 323.8±2.1 | 402.5±23.8c | 389.2±35.3 | 303.3±7.3e |
| SOD (U/mgprot) | 175.3±13.5 | 162.0±16.8 | 128.8±5.3a | 166.1±13.9d | 195.7±19.2e |
| GSH-Px (U/mgprot) | 322.4±20.9 | 282.2±12.0 | 269.2±1.9a | 358.2±28.0d | 412.7±36.5e |
| Hypothalamus | |||||
| ROS (U/mgprot) | 126.0±11.8 | 138.8±8.9 | 176.6±12.6b | 144.2±9.9d | 131.9±8.2d |
| SOD (U/mgprot) | 132.7±10.9 | 118.6±4.3 | 68.2±3.7c | 92.6±6.5e | 107.4±9.8e |
| GSH-Px (U/mgprot) | 212.8±20.7 | 220.1±7.7 | 121.9±10.2b | 199.0±18.6d | 211.4±15.9e |
Data are expressed as the mean ± the standard error of the mean (n=10).
a
P<0.05,
b
P<0.01 and
c
P<0.001 vs. control mice.
d
P<0.05 and
e
P<0.01 vs. AD mice. ROS, reactive oxygen species; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; AlCl3, aluminum trichloride; d-gal, d-galactose.