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. 2018 Dec 18;43(2):807–820. doi: 10.3892/ijmm.2018.4035

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Roles of PI3K/Akt in IGF-1 induced neuroprotection in vitro. (A) Morphological changes of cultured DRG neurons following treatment with DMSO (control), LY294002, scrambled siRNA (control) and Akt siRNA in cultured DRG neurons transfected with HSV-IGF-1 (magnification, ×200). (B) Representative blots of PI3K, pPI3K, Akt and pAkt proteins detected by western blot analysis. The ratios of pPI3K/PI3K and pAkt/Akt are also shown. Values are plotted as the mean ± standard deviation (n=5). IGF-1, insulin-like growth factor 1; DRG, dorsal root ganglia; siRNA, small interfering RNA; PI3K, phosphatidylinositol 3-kinase; pPI3K, phosphorylated PI3K; pAkt, phosphorylated Akt; DMSO, dimethyl sulfoxide.