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Proteolytic process of myocilin through calpain II (40). The proteo-lytic processing of myocilin is carried out by calpain II in the endoplasmic reticulum, producing two myocilin fragments: One containing LZ that is intracellularly retained and another containing OLF that is extracellularly secreted. Some full-length myocilins with LZ and OLF are also secreted. LINK contains the cleavage site. LZ, leucine zippers; OLF, olfactomedin; LINK, linker domain.
