Table III.
Identified gene ontology terms of the MO and MOMa groups compared with the C group.
| Geneset name | MO/C
|
MOMa/C
|
||||
|---|---|---|---|---|---|---|
| No. of genes in geneset | No. of genes in overlap | P-value | No. of genes in geneset | No. of genes in overlap | P-value | |
| GO:0001846-opsonin binding | N.I. | 7 | 3 | <0.01 | ||
| GO:0001871-pattern binding | 116 | 7 | <0.01 | 116 | 13 | <0.01 |
| GO:0001872-zymosan binding | 3 | 2 | 0.02 | 3 | 2 | 0.04 |
| GO:0003924-GTPase activity | 98 | 4 | 0.05 | N.I. | ||
| GO:0003779-actin binding | N.I. | 233 | 10 | 0.01 | ||
| GO:0004857-enzyme inhibitor activity | 238 | 10 | <0.01 | 238 | 11 | <0.01 |
| GO:0004859-phospholipase inhibitor activity | 6 | 2 | 0.05 | N.I. | ||
| GO:0004866-endopeptidase inhibitor activity | 148 | 6 | 0.01 | 148 | 7 | 0.02 |
| GO:0005125-cytokine activity | 110 | 5 | 0.01 | N.I. | ||
| GO:0005506-iron ion binding | 289 | 7 | 0.03 | 289 | 10 | 0.03 |
| GO:0005525-GTP binding | 312 | 8 | 0.02 | N.I. | ||
| GO:0005509-calcium ion binding | N.I. | 672 | 20 | 0.01 | ||
| GO:0005529-sugar binding | N.I. | 215 | 9 | 0.02 | ||
| GO:0005539-glycosaminoglycan binding | 102 | 5 | 0.01 | 102 | 11 | <0.01 |
| GO:0008009-chemokine activity | 32 | 5 | <0.01 | 32 | 4 | 0.01 |
| GO:0008201-heparin binding | 72 | 4 | 0.02 | 72 | 8 | <0.01 |
| GO:0016175-superoxide-generating | N.I. | 7 | 3 | <0.01 | ||
| NADPH oxidase activity | ||||||
| GO:0016814~hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 22 | 3 | 0.01 | 22 | 4 | <0.01 |
| GO:0019239-deaminase activity | N.I. | 21 | 3 | 0.04 | ||
| GO:0019001-guanyl nucleotide binding | 326 | 8 | 0.02 | N.I. | ||
| GO:0019763-immunoglobulin receptor activity | 7 | 3 | <0.01 | 7 | 3 | <0.01 |
| GO:0019770-IgG receptor activity | 4 | 2 | 0.03 | N.I. | ||
| GO:0019834-phospholipase A2 inhibitor activity | 3 | 2 | 0.02 | 3 | 2 | 0.04 |
| GO:0019863-IgE binding | 4 | 2 | 0.03 | N.I. | ||
| GO:0019864-IgG binding | 6 | 4 | <0.01 | 6 | 4 | <0.01 |
| GO:0019865-immunoglobulin binding | 12 | 5 | <0.01 | 12 | 5 | <0.01 |
| GO:0019955-cytokine binding | 87 | 4 | 0.04 | 87 | 7 | <0.01 |
| GO:0020037-heme binding | 148 | 5 | 0.04 | 148 | 7 | 0.02 |
| GO:0030246-carbohydrate binding | 337 | 10 | <0.01 | 337 | 20 | <0.01 |
| GO:0030247-polysaccharide binding | 116 | 7 | <0.01 | 116 | 13 | <0.01 |
| GO:0030414-peptidase inhibitor activity | 159 | 7 | <0.01 | 159 | 8 | 0.01 |
| GO:0032403-protein complex binding | N.I. | 222 | 12 | <0.01 | ||
| GO:0032561-guanyl ribonucleotide binding | 326 | 8 | 0.02 | N.I. | ||
| GO:0042379-chemokine receptor binding | 33 | 5 | <0.01 | 33 | 4 | 0.01 |
| GO:0042802-identical protein binding | 588 | 11 | 0.02 | 588 | 18 | 0.01 |
| GO:0042803-protein homodimerization activity | 318 | 8 | 0.02 | 318 | 15 | <0.01 |
| GO:0046906-tetrapyrrole binding | 154 | 5 | 0.04 | 154 | 7 | 0.03 |
| GO:0046983-protein dimerization activity | 528 | 10 | 0.03 | 528 | 20 | <0.01 |
| GO:0048020-CCR chemokine receptor binding | 3 | 2 | 0.02 | N.I. | ||
| GO:0050664-oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor | N.I. | 11 | 3 | 0.01 | ||
N.I., not identified; Ig, immunoglobulin; GO, Gene Ontology; C, control (saline infusion/vehicle injection/saline challenge); Mo, morphine (morphine infusion/vehicle injection/morphine challenge); Ma, melatonin (morphine infusion/melatonin injection/saline challenge); MOMa, (morphine infusion/melatonin injection/morphine challenge).