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Smad7 enhances the effect of miR-27a on osteogenic differentiation of MC3T3-E1 cells. (A) Cell proliferation and (B) osteogenic differentiation of MC3T3-E1 cells (magnification, ×100). ##P<0.01 vs. control group, **P<0.01 vs. miR-27a mimics group. Groups: Control, negative control group; miR-27a, miR-27a mimics group; Smad7, miR-27a mimics + Smad7 group. miR, microRNA.
