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. Author manuscript; available in PMC: 2019 Mar 3.
Published in final edited form as: Nat Microbiol. 2018 Sep 3;3(11):1206–1213. doi: 10.1038/s41564-018-0223-6

Fig. 4. PBANKA_0312700 is an AP2-G-induced gene involved in gametocyte development.

Fig. 4

A. PBANKA_0312700 gene structure with conserved helicase domains and putative AP2-G binding motif marked.

B. Representative FACS analysis (from 4 independent experiments) showing loss of male gametocytes in the PBANKA_0312700 KO.

C. Ookinete conversion in PBANKA_0312700 KO crossed with line producing only viable females (p48/45-) or males (p47-), showing that the defect gametocyte development is male specific. Means, standard deviations and individual data points from three independent biological replicates are shown. Statistical significance was determined with a two tailed, unpaired Student’s t-test.

D. Model of AP2-G function in gametocyte commitment.