Table 2.
Baseline Peripapillary RNFL Thickness on Optical Coherence Tomography
| Ranibizumab | Prompt PRP | |||
|---|---|---|---|---|
| Average RNFL Thickness at Baseline* | ||||
| Lower than Normal | 16 (21%) | 11(16%) | ||
| Normal | 56 (73%) | 53 (77%) | ||
| Above Normal | 5 (6%) | 5 (7%) | ||
| Average RNFL Thickness at Baseline within Each Quadrant | ||||
| Heidelberg Spectralis | Zeiss Cirrus | Heidelberg Spectralis | Zeiss Cirrus | |
| N = 40 | N = 37 | N = 39 | N = 30 | |
| Inferior | ||||
| Mean ± SD | 123.6 ± 29.2 | 113.5 ± 29.1 | 125.7 ± 26.9 | 115.4 ± 20.6 |
| Median – 25th, 75th percentile | 130 (105,139) | 110 (92,134) | 124 (105,146) | 109 (96,129) |
| Superior | ||||
| Mean ± SD | 114.2 ± 22.1 | 112.1 ± 22.1 | 114.3 ± 24.4 | 111.4 ± 21.8 |
| Median – 25th, 75th percentile | 117 (99,130) | 110 (96,122) | 113 (97,132) | 108 (96,127) |
| Nasal | ||||
| Mean ± SD | 70.5 ± 18.3 | 72.3 ± 17.8 | 71.9 ± 18.7 | 71.8 ± 13.7 |
| Median – 25th, 75th percentile | 67 (59,81) | 68 (62,81) | 70 (57,86) | 70 (64,79) |
| Temporal | ||||
| Mean ± SD | 78.4 ± 15.7 | 71.4 ± 22.5 | 74.7 ± 16.4 | 72.4 ± 18.7 |
| Median – 25th, 75th percentile | 76 (70,87) | 66 (57,79) | 71 (63,88) | 69 (56,91) |
| Average | ||||
| Mean ± SD | 96.8 ± 18.2 | 92.7 ± 19.9 | 96.8 ± 19.3 | 94.8 ± 21.2 |
| Median – 25th, 75th percentile | 96 (85,106) | 90 (78,104) | 95 (82,112) | 89 (81,102) |
PRP = panretinal photocoagulation; RNFL = retinal nerve fiber layer
*
Lower than normal defined as < 76.9 µm for cirrus and < 80.4 µm for Heidelberg OCT; normal defined as 76.9-120.5 µm for cirrus and 80.4-131.6 µm for Heidelberg OCT; above normal defined as > 120.5 µm for cirrus and >131.6 µm for Heidelberg OCT RNFL normal range defined as within ± 2SDs from the instrument specific norm of the population