Table 3.

Mean Change in RNFL Thickness Measurements from Baseline to 1 and 2 Years

RNFL Quadrant (µm)	Ranibizumab Mean ± SD*	Prompt PRP Mean ± SD	Adjusted Mean Difference† (95%CI)	P-value
1 year	N = 73	N = 57
Inferior	−12.4 ± 17.7	−2.7 ± 14.1	−9.7 (−14.8, −4.6)	<0.001
Superior	−9.3 ± 12.1	−3.5 ± 14.3	−5.7 (−9.1, −2.3)	<0.001
Nasal	−7.9 ± 9.6	−1.3 ± 10.0	−7.3 (−9.9, −4.7)	<0.001
Temporal	−7.7 ± 11.4	+1.8 ± 11.1	−9.4 (−12.6, −6.2)	<0.001
Average	−9.6 ± 10.8	−1.9 ± 12.3	−7.4 (−10.0, −4.9)	<0.001
2 years	N = 74	N = 66
Inferior	−14.8 ± 18.8	−6.5 ± 16.8	−7.6 (−11.6, −3.7)	<0.001
Superior	−11.9 ± 14.7	−6.4 ± 16.0	−4.5 (−8.4, −0.6)	0.023
Nasal	−8.8 ± 10.4	−3.1 ± 10.0	−5.5 (−8.0, −2.9)	<0.001
Temporal	−7.4 ± 13.0	+0.8 ± 13.3	−7.6 (−11.4, −3.8)	<0.001
Average	−10.9 ± 11.7	−4.3 ± 11.6	−4.9 (−7.2, −2.6)	<0.001

PRP= panretinal photocoagulation; RNFL = retinal nerve fiber layer

^*Truncated to ± 3 standard deviation from the mean; inferior, 3 eyes; superior, 3 eyes; nasal, 1 eye; temporal, 2 eyes; average, 2 eyes.

^†Adjusted mean difference, confidence intervals obtained from ANCOVA model adjusting for baseline RNFL thickness measurements, central subfield thickness and laterality