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. Author manuscript; available in PMC: 2019 Jan 3.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2016 Jan 27;25(2):250–258. doi: 10.1158/1055-9965.EPI-15-0946

Table 2.

Invasive cancer IRsa by primary site, Appalachian Region and US non-Appalachiab, males and females, all races, 2004–2011

Southern
Appalachia
Central
Appalachia
Northern
Appalachia
All
Appalachia
US non-
Appalachia
Males
rate
Females
rate
Males
rate
Females
rate
Males
rate
Females
rate
Males
rate
Females
rate
Males
rate
Females
rate
All sites 568.7c 402.3c 561.6c 427.2c 567.1c 449.3c 565.8c 428.7c 543.0 418.2
Oral cavity and pharynx 18.9c 6.6c 18.0c 6.4 16.7 6.3 17.8c 6.4c 16.5 6.2
Esophagus 8.0c 1.6c 8.6 1.6c 10.0g 1.9 9.0c 1.7c 8.5 1.9
Stomach 8.7c 4.4c 8.1c 3.9c 10.0c 4.2c 9.0c 4.2c 9.5 4.7
Colon and rectum 55.0c 39.1 55.5c 41.0c 58.0c 43.8c 56.6c 41.8c 52.4 39.5
Liver and intrahepatic bile duct 9.2c 2.9c 8.0c 2.7c 8.2c 2.6c 8.4c 2.8c 10.7 3.6
Pancreas 13.7 10.2c 12.8c 9.5c 14.2c 11.0c 13.6 10.3c 13.7 10.7
Larynx 8.5c 1.9c 8.8c 2.3c 7.4c 1.7c 8.2c 2.0c 6.6 1.4
Lung and bronchus 101.9c 56.5c 110.4c 67.0c 89.4c 58.2c 100.4c 61.0c 79.5 54.7
Melanoma of the skin (whites) 31.8c 22.6c 28.9c 19.8c 21.3c 15.9c 27.4 19.1c 27.4 17.8
Breast - 145.5c - 138.4c - 151.3c - 145.2c - 153.0
 Invasive - 117.3c - 115.0c - 121.5 - 118.2c - 122.4
In situ - 28.2c - 23.4c - 29.7c - 27.0c - 30.5
Cervix uteri - 8.2 - 8.8c - 7.9 - 8.3c - 7.9
Corpus and uterus, NOS - 18.8c - 24.5 - 31.1c - 25.2c - 24.5
Ovary - 12.4 - 12.4 - 13.4c - 12.7c - 12.3
Prostate 150.6c - 130.2c - 142.6c - 139.9c - 147.0 -
Testis 4.5c - 5.3 - 6.7c - 5.5 - 5.5 -
Urinary bladder 34.5c 7.8c 37.7c 9.4 45.4c 11.3c 39.8c 9.7c 37.0 9.3
Kidney and renal pelvis 21.2 11.1 21.8c 11.9c 20.8 11.8c 21.2 11.7c 21.1 11.0
Brain and other nervous system 8.0 5.9 8.3c 6.1c 8.4c 6.1c 8.3c 6.1c 7.9 5.7
Thyroid 5.0c 14.6c 5.9 17.4 7.7g 25.5c 6.3c 19.2c 6.0 17.7
Hodgkin Lymphoma 3.0 2.2c 2.9c 2.3 3.6c 2.9c 3.1 2.5 3.2 2.5
Non-Hodgkin lymphoma 21.5c 14.9c 23.1 16.2 24.6c 17.7c 23.3 16.4 23.4 16.3
Myeloma 7.6 4.9 7.2 4.5c 7.1c 4.6c 7.3c 4.7c 7.5 4.9
Leukemia 16.0c 9.8c 16.9 10.3 17.6c 10.9c 16.9 10.4c 16.7 10.2

Abbreviation: NOS, not otherwise specified.

a

Rates are per 100,000 persons age-adjusted to the 2000 US standard population.

b

Southern Appalachia includes Alabama, Georgia, Mississippi, and South Carolina; Central Appalachia includes Kentucky, North Carolina, Tennessee, Virginia, and West Virginia; Northern Appalachia includes Maryland, New York, Ohio, and Pennsylvania; US non-Appalachia includes all counties not in Appalachia.

c

The rate ratio indicates that the rate is significantly different than the US non-Appalachia rate (P < 0.05).