Table 1.

Polymer and NPC characteristics^Δ used in this study

	Polymers															NPC
	Corona Block				Core Block						Diblock Copolymers
Polymer	DP	Block 1Mn1(kDa)		PDI	DP	Block 2Mn1(kDa)		%DMAEMA2	%BMA2	%PAA2	OverallMn1(kDa)		PDI	CCR		Size3(nm)		ζ4(mV)
NP12/2	100	12.4	α	1.05	40	2.1	α	17	57	26	14.5	α	1.04	5.9	ν	7.7 ± 2.9	ρ	18.3 ± 3.8
NP12/3a	100	12.4	α	1.05	65	3.1	α	11	38	51	15.5	α	1.05	4.0	λ	20.5 ± 5.7	σ	15.8 ± 5.0
NP12/3b	100	12.4	α	1.05	65	3.2	α	2	54	44	15.6	α	1.05	3.9	κ	17.1 ± 4.5	ρ	20.1 ± 3.5
NP12/3c	100	12.4	α	1.05	65	3.2	α	18	38	44	15.6	α	1.04	3.8	κ	12.9 ± 4.7	ρ	16.1 ± 4.3
NP12/4	100	12.4	α	1.05	65	3.5	α	5	62	33	15.9	α	1.04	3.5	κ	13.8 ± 4.3	ρ	18.6 ± 4.1
NP12/5	100	12.4	α	1.05	120	5.2	α	1	66	33	17.6	α	1.04	2.4	ι	20.6 ± 5.3	σ	21.3 ± 4.4
NP12/12	100	12.4	α	1.05	300	11.6	α	7	73	20	24.0	β	1.06	1.1	θ	29.4 ± 7.3	σ	23.2 ± 4.1
NP13/2	105	12.7	α	1.07	35	2.4	α	8	57	35	15.2	α	1.04	5.3	ν	9.1 ± 3.8	ρ	20.5 ± 4.4
NP13/3	105	12.7	α	1.07	35	3.1	α	27	59	15	15.8	α	1.04	4.1	λ	15.1 ± 4.1	ρ	20.4 ± 3.9
NP13/4	105	12.7	α	1.07	35	3.5	α	37	57	6	16.2	α	1.04	3.6	κ	18.6 ± 4.6	ρ	19.7 ± 4.2
NP13/5	105	12.7	α	1.04	40	4.7	α	51	27	22	17.4	α	1.06	2.7	ι	11.3 ± 5.2	ρ	19.6 ± 4.4
NP13/31	100	13.0	α	1.04	1000	30.8	β	8	66	26	43.8	γ	1.02	0.4	η	69.1 ± 20.8	τ	14.3 ± 3.9
NP47/25	600	47.1	γ	1.08	1000	24.9	β	2	46	52	72.0	δ	1.02	1.9	θ	63.5 ± 21.3	τ	19.6 ± 5.1
NP52/15	800	52.2	γ	1.13	350	14.6	α	33	32	35	66.8	δ	1.05	3.6	κ	30.8 ± 9.4	σ	18.1 ± 4.4
NP99/50	1000	98.9	ε	1.05	2000	49.6	γ	3	58	39	148.5	ε	1.05	2.0	θ	106.0 ± 53.2	υ	20.0 ± 4.0
NP99/104	1000	98.9	ε	1.05	4000	104	ε	3	69	29	202.9	ε	1.05	1.0	η	90.9 ± 40.7	υ	24.6 ± 3.8

^ΔAs characterized by

¹gel permeation chromatography

²nuclear magnetic resonance

³dynamic light scattering, and

⁴electrophoretic light scattering.

Abbreviations: CCR, corona-to-core molecular weight ratio; DP, target degree of polymerization; PDI, polydispersity index (M_w/M_n); ζ, zeta potential. Groups identified for data analysis: M_n, α = 1–20 kDa, β = 20–40 kDa, γ = 40–60 kDa, δ = 60–80 kDa, ε ≥ 80 kDa; CCR, η ≤ 1, θ = 1–2, ι = 2–3, κ = 3–4, λ = 4–5, ν ≥ 5; Size, ρ = 1–20 nm, σ = 20–40 nm, τ = 60–80 nm, υ ≥ 80 nm.