Table 2. Odds Ratio for overweight/obesity (BMI≥25kg/m2) in 17-year-old offspring associated with cesarean vs. vaginal delivery.
Model 1a | Model 2b | |||||||
---|---|---|---|---|---|---|---|---|
OR | p-value | 95% CI | p_interactionc | OR | p-value | 95% CI | p_interactionc | |
Main analyses | 1.42 | 0.001 | 1.16–1.74 | 0.013 | 1.44 | 0.002 | 1.14–1.82 | 0.014 |
Restricted analysesd | 1.43 | 0.002 | 1.14–1.78 | 0.106 | 1.49 | 0.002 | 1.16–1.92 | 0.086 |
a Adjusted for maternal education, socioeconomic status, ethnicity and offspring sex
b Further adjusted for proxies for indication for cesarean section (c-section), including toxemia, diabetes in pregnancy, multiple pregnancy, birth order, maternal age at delivery, smoking during pregnancy, preterm and post-term delivery, low and high birth weight and previous c-section
c Interaction was examined by adding cross-product terms between upper quartile of maternal pre-pregnancy BMI (vs. rest) and mode of delivery to the multivariable model
d Subgroup of singleton first births within the cohort, without toxemia or diabetes in pregnancy. The restricted sample included 9,160 offspring born vaginally and 631 born by c-section, of which 1,089 and 102 were overweight/obese, respectively.