TABLE 1.
Subject Demographics and Characteristics
| Variable | MS Subjects, n = 520a | Healthy Controls, n = 81a | pb |
|---|---|---|---|
| Age at study entry, yr | 42.7 ± 9.8 | 41.1 ± 9.7 | 0.2 |
| Gender | 0.4 | ||
| Female | 365 (70.2) | 53 (65.4) | |
| Male | 155 (29.8) | 28 (35.6) | |
| Disease course | N/A | ||
| CIS | 90 (17.3) | ||
| RRMS | 392 (75.4) | ||
| SPMS | 38 (7.3) | ||
| Disease duration, yr | 9.2 ± 8.6 | N/A | |
| Mean EDSS at baseline | 1.8 ± 1.5 | N/A | |
| Cumulative DMT exposure | N/A | ||
| None | 116 (22.3) | ||
| ≤1 year | 33 (6.3) | ||
| 1–3 years | 77 (14.8) | ||
| 3–5 years | 107 (20.6) | ||
| >5 years | 187 (36.0) | ||
| Mean follow-up time, yr | 4.1 ± 1.6 | 1.3 ± 1.7 | |
| Total MRI time points analyzed | 2,485 | 147 | |
| MRI time points, No. | |||
| Subjects with 1 MRI | 18 | 41 | |
| Subjects with 2 MRIs | 46 | 19 | |
| Subjects with 3 MRIs | 51 | 17 | |
| Subjects with 4 MRIs | 49 | 3 | |
| Subjects with 5 MRIs | 110 | 1 | |
| Subjects with 6 MRIs | 246 | — |
a
Mean±standard deviation for continuous variables, No. (%) for categorical variables.
b
p-value for t test or chi-square test.
CIS=clinically isolated syndrome; DMT=disease-modifying therapy; EDSS=Expanded Disability Status Scale; MRI=magnetic resonance imaging; MS=multiple sclerosis; N/A=not applicable; RRMS=relapsing–remitting multiple sclerosis; SPMS=secondary progressive multiple sclerosis.