Figure 1.

Schematic of CaN peptide binding to CaM. The green and red peptides represent CaM conformations which are capable and incapable of binding to CaM (colored in cyan). The association rates between intrinsically-disordered CaN peptides and CaM are controlled by open/closed state gating kinetics (depicted by k_b and k_f) and the CaM/CaN diffusional encounter rate (depicted by k_on). Our study demonstrates that low (a) and high (b) ionic strengths influence both contributions to afford diffusion limited encounters