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. Author manuscript; available in PMC: 2019 Jan 3.
Published in final edited form as: Semin Nephrol. 2018 Mar;38(2):183–192. doi: 10.1016/j.semnephrol.2018.01.007

Figure 2.

Figure 2.

Glycolytic pathways for the generation of critical substrates in glycosphingolipid synthesis. (A) Major intermediates and products of aerobic glycolysis. In the presence of growth factors such as epidermal growth factor, glucose metabolism generates acetyl-CoA, serine, UDP glucose, and NADPH. (B) Denotes the points at which the products of aerobic glycolysis are used for the synthesis of glucosylceramide. Abbreviations: CoA, coenzyme A; EC, extra-cellular; FBP, fructose 1,6-bisphosphate; PEP, phosphoenolpyruvate; UDP, uridine diphosphate; UTP, uridine triphosphate.