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Under normal conditions, the binding of micro RNA (miR)‐129‐5p to sex‐determining region Y‐box 2 (SOX2) mRNA leads to the degradation of SOX2 mRNA, thus maintaining normal levels of SOX2. In the case of Opa interacting protein 5‐antisense RNA 1 (OIP5‐AS1) overexpression, OIP5‐AS1 competitively binds with miR‐129‐5p as a miRNA sponge and releases SOX2 mRNA from the inhibitory effect of miR‐129‐5p. The increased SOX2 can thus promote the malignant phenotype of breast cancer
