Figure 7.

ER‐α36‐specific modulator IC162 enhanced autophagy, which was induced by tamoxifen (TAM). Combined treatment of TAM with IC162, ICI182,780, PPT, 3‐MA or CQ on glioblastoma U87 cells. All groups underwent agonist or inhibitor precondition for 2 h, then were exposed to 5 μmol/L TAM for 0 h or 4 h. A, MTT analysis of the viability of glioma cells. B, Western blot analysis of the accumulation of LC3‐II (n = 3, **P < .01 vs control; ^## P < .01 vs TAM). 3‐MA, methyladenine; CQ, chloroquine; ER, estrogen receptor