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. 2018 Dec 13;110(1):157–165. doi: 10.1111/cas.13867

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© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Transcriptomic analyses of differentially expressed transcription factor genes in The Cancer Genome Atlas (TCGA) liver hepatocellular carcinoma (LIHC) cohort. A, Heatmaps of unsupervised clustering of differently expressed transcription factor genes in 50 pairs of normal and hepatocellular carcinoma (HCC) samples from TCGA LIHC cohort, with rows representing genes and columns representing samples. B, Track 1 shows 100 upregulated (red boxes) and 10 downregulated (green boxes) transcription factor genes in liver HCC samples. P‐values on track 2 were generated from Kaplan‐Meier analysis of overall survival. Track 3 shows the fold‐change of differentially expressed genes, and track 4 shows somatic mutation frequency. Genes whose expression levels were significantly associated with overall patient survival are shown in red. C, Correlation of clinicopathological features with tumor DEP domain containing 1 (DEPDC1) expression level in TCGA LIHC cohort