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. 2018 Dec 15;110(1):118–134. doi: 10.1111/cas.13864

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© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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RUN and FYVE domain containing 1 (RUFY1) knockdown attenuated podocalyxin‐like protein (PODXL)‐induced tumorigenesis in vivo. A, RUFY1 knockdown significantly inhibited tumorigenesis in nude mice and attenuated the PODXL‐induced changes in tumor formation. B, Tumor growth curves were generated each week. C, Tumor weights were compared. D, E, Histological analysis revealed that RUFY1 knockdown significantly decreased the expression of Ki67 and the levels of p‐Akt and p‐NF‐κB expressions, and attenuated the PODXL‐induced changes of signaling proteins (*P < .05)